Unravelling the role of huntingtin: from neurodevelopment to neurodegeneration 

The journal, Brain, highlights a recent paper on “Genetic topography and cortical cell loss in Huntington’s disease link development and neurodegeneration“. A review by Schultz et al., succinctly summarizes intriguing findings that correlate a decrease in synaptic and metabolic genes with the loss of cortical cells along with posing overarching questions related to the neurodevelopmental aspects of Huntington’s disease.

Read the original article here: https://academic.oup.com/brain/article/146/11/4532/7243440

Read the review article here: https://academic.oup.com/brain/article/146/11/4408/7304367

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